Scientists from Yale University have found a way to cause an effective immune response to “complex” cancer tumors using Lupus -related antibodies. Research Results published Scientification in science signaling.
Scientists focused on “cold” tumors, also called “immune deserts”. Such neoplasms usually have a small number of immune cells, so they are treated weakly, including immunotherapy. However, treatment results can be developed using antibodies associated with another brightness disease.
After the launch of mice with brain cancer, an antibody called 4H2 warned a special kind of immune response. When he entered the cytoplasm of the cell (liquid content), it was associated with RNA and activated a special nucleic acid CGA sensor. The CGAS-Sting path is a component of an innate immune system that triggers an inflammatory reaction for brain cancer.
Scientists also found that the Lupus carrier offers genes to cells without virus assistance, which means that it can be used to transform genetic treatment strategies. In addition, 4H2 does not affect tissues without functional immune cells that reduce the likelihood of side effects.
Previously, scientists Eliminated The main obstacle to genetic treatment of cancer and diabetes.
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Source: Gazeta
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