Scientists made a breakthrough to understand how hot the pain was 02:12

American scientists from the University of Buffalo found how the Trpv1 receptor protein, which was responsible for the sense of heat and pain, activates it. The opening may become the basis for the development of new methods to treat pain. The results of the study have been published scientifically magazine Proceedings of National Science Academies (PNAs).

The TRPV1 receptor, located on the nerve endings of the skin, plays an important role in temperature and pain perception. It also reacts to Kapsaisin, a substance that makes pepper pepper sharp. However, it is still unclear how the temperature activates this receptor.

Experts have found that the Trpv1 protein, which leads to the activation of heat, has been partially deployed. This is an unusual mechanism, because most protein holds its structures for appropriate functioning.

To examine the activation mechanisms, scientists used a technology that allows you to quickly heat samples – up to half billions of 60-70 ° C at room temperature. This, for example, imitates the reaction rate when a person pulls his hand from a warm surface.

The researchers also applied differential scanning calorimetry (DSK) to measure how heat affects the structure of the protein. When heated by the TRPV1 receptor, they found that their activation was randomly opened, not to activation of a certain sensor, but to the exposure of overall heat.

Understanding TrpV1 activation mechanisms can help develop new pain methods. Traditional approaches such as the full lock of the receptor may cause side effects, including temperature sensitivity and violation of hypothermia.

Discovery may be useful for the development of biosensors that respond to temperature changes and to examine other thermal sensitive biological processes.

Previously, scientists Created A new analgesic drug without harmful side effects.