Scientists of the University of Science and Technology of Sirius patented a new way to fighting obesity. At the University of Sirius, Gazete.
The PRDM16 gene plays an important role in the process of making ordinary fat cells (white oil) more active beige. These cells have a unique ability to secrete heat by burning accumulated fats that significantly increases the body’s energy consumption.
To give the gene, biotechnologists used Adenoassed virus. Such viruses are safe: they do not cause diseases and are not integrated into cell DNA. The virus transmits the PRDM16 gene directly to the fat cells. Once they reach them, this gene contains ”production of protein responsible for burning fat. In this way, the body begins to spend more energy even without physical effort.
Researchers have tested new technology on mice with a mutation that caused obesity and type 2 diabetes development. After introducing scientists to the special vehicle to give the animal Prdm16 gene, their weight began to significantly decrease.
“Modern genetic therapy offers various opportunities to encourage the transformation of white fat tissue cells into beques. Most approaches to obesity use the possibility of induce the transition from white to beige tissue with the super expression of genes encoding the secreted factors: leptin, FGF21 or BMP7. We decided to go to the other side. Genotherapeutic drugs based on giving individual transcription factors may have different characteristics. This allows you to limit the effect of the drug on the tissues that are interested and reduce the risks of negative consequences. ”
Previously, scientists Proposed Use titanium plates to prevent miscarriage.
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Source: Gazeta
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