Researchers from the La-Hoya Institute of Immunology found that PINK1 protein could play an important role in the development of Parkinson’s disease. It turned out that some people accidentally attacked brain cells containing this protein. Published in İş Magazine Journal of Clinical Research (JCI).
Protein PINK1 usually helps brain cells regulate mitochondria responsible for energy production. However, in some patients with Parkinson’s disease, immune T cells begin to perceive PINK1 as a threat and attack neurons that cause inflammation and death of cells.
“A new study allows you to better understand the role of the immune system in the development of Parkinson’s disease, Prof said Professor Alessandro Sette, the leading author of the study.
Discovery can explain why Parkinson’s disease is about twice as frequent than women in men. Scientists have found that the number of T cells responding to PINK1 in Men with Parkinson has increased six times compared to healthy men. In women with this disease, this growth added only 0.7.
“The differences in the immune response in men and women were striking, Set Sett added. “This factor may be one of the reasons why men are more sensitive to Parkinson’s illnesses.”
The study of researchers gives hope for the early diagnosis of the disease. The identification of specific T cells attacking PINK1 may become a new biobelirt of Parkinson’s disease.
The joint author of the study. “We can improve the treatment that blocks these T cells, and now we know what they are for, Ar Cecili Lindstam Arlehamn said.
PINK1 is not the only protein associated with Parkinson’s disease. Previously, scientists have already proved that many patients had an immune response of Alfa Sinukleine, another protein associated with brain inflammation. However, all Parkinson’s patients could not find T cells responding to alpha sinüklein, so researchers continue to look for new mechanisms for the development of the disease.
“We need to make a greater analysis to understand the progression of the disease and the differences between men and women. We are starting to understand exactly how Parkinson’s disease started. ”
Previously, scientists Developed An antibiotic that can stop the “arms race” with bacteria.
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Source: Gazeta
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