Scientists from Ugan University (China) found that 24-OHC cholesterol processing product provoked tax and dopaminergic neuron formation in the brain-two main symptoms of Parkinson’s disease. The results of the work published In Plos İkibi magazine.
Researchers found that 24-OHC, cholesterol metabolite were found in many people with Parkinson’s disease. With age, the concentration of the blood increases. Experiments showed that the blocking of an enzyme that converts cholesterol into 24-OHC damages dopamine neurons. This confirms that 24-OHC plays an important role in the progress of the disease.
Additional experiments on neurons grown under laboratory conditions show that 24-OHC makes the normal alpha synuclein protein harmful, which increases the spread of tax theory. This is the name of the pathological closures that provokes the degeneration of neurons in the brain and the deterioration of motor functions.
These results emphasize the potential efficiency of drugs that prevent cholesterol cholesterol-24-hydroxylase (CYP46A1) as a possible way to treat Parkinson’s disease. Scientists are planning to continue research to find out what effects the experimental treatment will have on volunteers.
Previously found Relationship between kidney failure and Parkinson’s disease.
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Source: Gazeta
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