A team of scientists from the National Defense Medical Center in Taiwan found that cancer patients treated with immune checkpoint inhibitors (ICIs) had an increased risk of developing psoriasis. The research was published in the scientific journal magazine JAMA Dermatology.
ICT is an important cancer treatment method that increases the immune system’s ability to fight tumor cells. However, its effect is associated with side effects caused by immune attacks on healthy organs.
Analysis of medical data from 135.2 thousand patients showed that ICT use was associated with an increase in psoriasis cases; 1.44 cases of disease per 1000 people compared to 5.76 cases of disease per 1000 people in the non-ICT group.
When scientists took other factors into account, it turned out that ICT increased the risk of developing psoriasis by more than three times.
Researchers determined that ICTs, specifically those targeting programmed cell death protein 1 and its ligand PD-L1, essentially block the function of proteins that normally act as brakes on the immune system.
The increased immune response causes T cells to mistakenly target healthy tissue, such as skin, increasing the likelihood of developing psoriasis.
The mechanism reflects how ICTs may trigger other immune events by enhancing pro-inflammatory T helper cell responses, the researchers noted.
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Source: Gazeta
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