Nutrient sensor molecules have been found in human intestinal cells. They can regulate digestion and appetite, according to a study published in the journal. Science.
When food is consumed, hormones that are important for controlling appetite are secreted in the intestines. One of the most famous examples of drugs that mimic the action of one of these hormones is Ozempic.
Scientists have long been trying to find the molecules responsible for the release of intestinal hormones. Targeting these molecules rather than the hormones themselves could help develop effective drugs against many diseases. However, most of the research was done on mice.
In the new study, scientists used human organoids. These mini versions of human organs contain the same types of cells as the original organ. Biologists have identified many molecules involved in the release of intestinal hormones. They showed that when these molecules were blocked, hormone release stopped. This confirms the importance of the detected molecules.
In the future, the molecules identified may become targets as alternatives to Ozempic and other drugs against metabolic diseases and intestinal motility disorders. Doctors will be able to increase levels of desired gut hormones rather than mimic their effects.
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Source: Gazeta
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