Scientists from Yale School of Medicine found that excessively salty foods increase the activity of the PRDM1-S protein, which can impair T-cell function and cause disruptions in immune regulation associated with multiple sclerosis and other diseases. Research results It was published Science in the field of Translational Medicine (STM).
Scientists have explained that autoimmune diseases such as rheumatoid arthritis and lupus are caused by genetic and environmental factors, such as vitamin D and fatty acid deficiencies. Initial research by Yale School of Medicine scientists found that high salt intake also contributes to the development of multiple sclerosis.
A new study has found that a gene called PRDM1-S and a protein of the same name are both increased in patients with multiple sclerosis. It plays a role in regulating immune function. Scientists have found that PRDM1-S leads to increased expression of the salt-sensitive enzyme SGK-1, which in turn leads to the degradation of regulatory T cells. When you eat too much salty food, the T cells that normally control the immune response stop preventing autoimmune diseases.
According to scientists, the results of the study can be the basis for the creation of new drugs that will eliminate such pathologies. Most likely, their effect will be to suppress the activity of PRDM1-S.
Formerly a doctor in the name Foods that older people should avoid.
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Source: Gazeta
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