Fatty liver disease is closely related to impaired urea metabolism in the body. This was demonstrated by a study published in the journal. Cell Metabolism.
Nonalcoholic fatty liver disease (NAFLD) develops in many people who lead an unhealthy lifestyle, especially those who are obese. It causes fat to accumulate in the liver, which can lead to the need for a liver transplant. There is no cure for the disease because the mechanisms are unknown. In a new study, scientists have found possible drug targets for NAFLD.
In the new study, scientists found that impaired urea formation in the liver is caused by secondary disorders in the tricarboxylic acid cycle. This leads to inefficient utilization of calories and accumulation of fat in the liver. As a result, inflammation and fibrosis occur, which contribute to the further development of the disease.
In previous studies, scientists found that drugs that target the urea cycle significantly alleviated NAFLD symptoms in mice. The new study confirms that this could be an effective treatment approach.
Earlier scientists named Medicines that can cause serious liver damage.
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Source: Gazeta
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