Scientists from the Francis Crick Institute and University College London have shown that increased concentrations of PM2.5 particles in the air increase the risk of non-small cell lung cancer in non-smokers with mutations in the EGFR gene. published In the journal Nature.
Scientists say that tiny air pollution particles called PM2.5 can activate dormant mutations in the lung cells of non-smokers, which can ultimately lead to the development of cancer. PM2.5 particles can have a variety of origins, including mineral salts, soot, rubber, sand and asphalt, heavy metal compounds, pollen, waste products of microorganisms, bacteria, and small liquid and gas droplets.
Laboratory studies on lung tissue samples confirmed that PM2.5 particles cause changes in airway cells with mutations in the EGFR and KRAS genes. Undesirable variants in these genes are associated with an increased risk of lung cancer. PM2.5 particles stimulate an inflammatory response in macrophages (cell powerhouses) and the transition of lung epithelial cells to a stem cell-like state.
The scientists also found that 18-33% of normal lung tissue samples from volunteers contained mutations in the EGFR and KRAS genes, even in the absence of malignancy. This means that many people have dormant mutations that can be activated by adverse environmental exposures.
Researchers have found that blocking the inflammatory protein IL1B can prevent the formation of tumors caused by PM2.5 particles in mice. This opens up opportunities for the development of new methods for the prevention and treatment of lung cancer.
Formerly a doctor It has been said About the asymptomatic stage of lung cancer.
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Source: Gazeta
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