Scientists at Karolinska Institute have discovered that reducing the activity of mitochondria (the powerhouses of cells) can reverse diet-induced obesity, fatty liver disease and diabetes in mice. Research results published In the journal Nature Metabolism.
Mitochondria are components of cells that convert nutrients from incoming food into energy. They are central regulators of metabolism.
To test whether reducing the energy efficiency of cells would benefit the body, scientists conducted an experiment on mice. A group of rodents were fed high-calorie, fatty foods to cause them to develop obesity, diabetes and fatty liver disease. At the end of the dietary intervention period, the animals were exposed to a new drug that blocks mitochondrial energy production.
After four weeks of experimental treatment, the mice regained glucose tolerance, the amount of fat accumulated in the liver decreased, and body weight decreased significantly. These signs are indicators of the restoration of normal metabolic function.
Scientists are now trying to further study the mechanisms underlying the new drug’s action. Researchers have also begun to evaluate the drug’s effectiveness and safety in treating metabolic diseases in humans.
used to be a doctor explainedHow to avoid the carcinogenic effects of sugar?
What are you thinking?
Source: Gazeta
Barbara Dickson is a seasoned writer for “Social Bites”. She keeps readers informed on the latest news and trends, providing in-depth coverage and analysis on a variety of topics.