Scientists are closer to understanding the causes of EMBO, a dangerous form of arthritis: psoriatic arthritis is associated with increased production of special oxygen species 12:21

Scientists from the Karolinska Institute in Sweden have discovered that rare and dangerous psoriatic arthritis (Arthritis mutilans) may be related to the action of a special enzyme that produces bone-damaging oxygen radicals. results published In the journal EMBO (European Molecular Biology Organization) Molecular Medicine.

Debilitating psoriatic arthritis (Arthritis mutilans) is a rare and very serious form of psoriasis characterized by destruction of the bone tissue and joint structures of the fingers and toes. It is stated that the exact cause of this pathology has not yet been determined. To fill this knowledge gap, Swedish scientists focused on finding genetic risk factors in the development of this disease.

For the study, researchers analyzed the genomes of 61 patients with psoriatic arthritis. They found that four of the subjects were carriers of a rare variant of the NADPH oxidase 4 (NOX4) gene. He hypothesized the presence in the body of a specific enzyme that produces oxygen radicals.

Scientists explained that oxygen radicals are reactive molecules that can cause cell damage. NOX4 also plays a role in the formation of cells called osteoclasts that destroy bone tissue. According to researchers, the combined effect of osteoclasts and oxygen radicals is the cause of damage to bones and joints in psoriatic arthritis. They hope that their discovery will contribute to the development of new treatments based on gene therapy for this disease.

Previous scientists defined A new way to fight inflammation in autoimmune diseases.

What are you thinking?



Source: Gazeta

Popular

More from author

The Ministry of Foreign Affairs called a very responsible topic for Putin and Trump 13:43

The restoration of relations between Russia and the United States is a very troublesome and difficult issue, has no right to make mistakes. This...

The Russians also explained how two pensions can be obtained 08:48

Some Russians can set two pensions at the same time - old age insurance and government disability. And in some cases, inhabitants have the...

They said which experts in Russia will replace with AI 13:36

Artificial Intelligence (AI) was able to replace the recruitment, secretaries and assistants. About This "Fifth Channel" said System analyst Denis podkovin. According to him, technical...

The winners of the appropriate cinema International Festival were recognized 13:30

The right film V festival was held in Moscow. This was reported to the "Gazeta.ru" in the press service of the Victory Museum. The closing...