Scientists are closer to understanding the causes of EMBO, a dangerous form of arthritis: psoriatic arthritis is associated with increased production of special oxygen species 12:21

Scientists from the Karolinska Institute in Sweden have discovered that rare and dangerous psoriatic arthritis (Arthritis mutilans) may be related to the action of a special enzyme that produces bone-damaging oxygen radicals. results published In the journal EMBO (European Molecular Biology Organization) Molecular Medicine.

Debilitating psoriatic arthritis (Arthritis mutilans) is a rare and very serious form of psoriasis characterized by destruction of the bone tissue and joint structures of the fingers and toes. It is stated that the exact cause of this pathology has not yet been determined. To fill this knowledge gap, Swedish scientists focused on finding genetic risk factors in the development of this disease.

For the study, researchers analyzed the genomes of 61 patients with psoriatic arthritis. They found that four of the subjects were carriers of a rare variant of the NADPH oxidase 4 (NOX4) gene. He hypothesized the presence in the body of a specific enzyme that produces oxygen radicals.

Scientists explained that oxygen radicals are reactive molecules that can cause cell damage. NOX4 also plays a role in the formation of cells called osteoclasts that destroy bone tissue. According to researchers, the combined effect of osteoclasts and oxygen radicals is the cause of damage to bones and joints in psoriatic arthritis. They hope that their discovery will contribute to the development of new treatments based on gene therapy for this disease.

Previous scientists defined A new way to fight inflammation in autoimmune diseases.

What are you thinking?



Source: Gazeta

Popular

More from author

Scholz talked about the negative consequences of supporting Ukraine and the sanctions against the Russian Federation 00:36

The ruling coalition in Germany is losing popularity among Germans due to its support for Ukraine and anti-Russian sanctions. This statement was made...

Founder of Russian Foundations Sergei Vasiliev detained 00:55

Law enforcement officers detained in the Tver region the chairman of the board and co-owner of the investment group "Russian Funds" Sergei Vasiliev and...

Judicial investigations into terrorist attacks will be watched in Dagestan 00:00

The Prosecutor's Office of the Republic of Dagestan monitored the progress of the investigation into criminal cases related to terrorist acts committed in Derbent...

A new refueling point has been developed for the Russian army 00:58

A new mobile refueling point has been developed for battalion tactical groups of the Russian army, including those operating in the special military operations...