Scientists identify a link between autism and some gut bacteria npj Biofilms: specific bacteria linked to behavioral disorders in autism 15:55

Scientists from Bar-Ilan University in Israel found that people with autism have increased levels of certain bacteria in their gut microbiomes that are associated with dysfunctional social behavior and dysregulated expression of certain genes. Research results published npj Biofilms and Microbiomes.

Over the past two decades, scientific interest in the connection between the state of the gut microbiota and various diseases has increased. Some studies have shown that bacterial imbalances in the gut can manifest as behavioral changes such as attention deficit hyperactivity disorder (ADHD).

When examining the gut microbiome of people with autism spectrum disorder (ASD), scientists found a significant increase in alpha diversity and abundance of bacteria of the division Bacteroidetes and the genus Bacteroides. To better understand the consequences of microbiome overpopulation by members of these groups, researchers introduced the bacterial strain Bacteroides fragilis into the intestines of newborn mice and allowed them to colonize.

They found that male mice exposed to B. fragilis developed social behavior impairment, increased repetitive behaviors (a hallmark of ASD), and dysregulation of the expression of autism-related genes in the prefrontal cortex.

The female mice showed no behavioral disorders, indicating that they are resistant to environmental factors that contribute to the development of autism.

Scientists explained that members of the Bacteroides genus, including B. fragilis, are essential for the normal functioning of the human intestine. However, the increase in their numbers could potentially be linked to behavioral problems. More research is needed to further analyze the changes caused by Bacteroidetes and Bacteroides in the brain.

Previously Appearedthat drugs that “heal” intestinal bacteria will help fight dementia.