In Russia, DNA fragments that penetrate tumor cells were synthesized for cancer treatment. This was reported by TASS Head of the Biomedical Chemistry Laboratory of the Institute of Chemical Biology and Fundamental Medicine SB RAS Elena Dmitrienko.
Scientists have developed modified DNA fragments, which are oligonucleotides that can penetrate a cancer cell and inhibit the development of tumor cells.
There are currently 18 approved drugs based on antisense oligonucleotides (antisense drugs), including drugs for the treatment of spinal muscular atrophy.
According to Dmitrienko, this success provides hope for cancer treatment. This means that the oligonucleotides can be modified and used in addition to standard cancer treatments or even as a separate drug.
However, this treatment method, in which antisense drugs are used, has disadvantages. First of all, it is poisonous. Oligonucleotides cannot penetrate the cell, so special delivery agents that are toxic are used for this. Secondly, a large amount of oligonucleotide material is needed for a therapeutic effect, so antisense drugs are very expensive.
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Source: Gazeta
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