Scientists from Duke University in the United States discovered that a procedure to surgically connect the circulatory systems of young and old mice slowed the cellular aging of older mice. The process of heterochronic parabiosis increases the life expectancy of older rodents by 10%. In this respect reports SciTechDaily.
Heterochronic parabiosis is a procedure for invasively connecting the circulatory systems of representatives of the same species of different ages.
During the experiment, scientists divided the mice into two groups. In the first group, two-year-old rodents were given the blood of four-month-old individuals for 12 weeks. Mice in the second group were not exposed to heterochronic parabiosis. After 12 weeks, the rodents in the first group became more active and lively, and their cells showed signs of rejuvenation.
The epigenetic age of blood and liver tissue of aged mice decreased due to heterochronic parabiosis. Additionally, individuals in the first group lived 10% longer than untreated animals. The rejuvenation effect continued for two months after the experiment was stopped.
The effects of parabiosis in a mouse study were equivalent to connecting the circulatory systems of a 50-year-old and an 18-year-old. At the same time, an elderly person’s life expectancy will increase by eight years.
However, the authors state that it is impractical and unethical to achieve heterochronic parabiosis with human participation. There are other anti-aging strategies, such as calorie restriction. They have been proven effective in mice and may be considered by humans.
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Source: Gazeta
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