Scientists from New York University found that blocking the Ebf3 protein in stem cells reduces bone loss associated with aging. The research was published in the journal Bone Research.
The Notch signaling pathway, a set of molecules through which different cells communicate, is responsible for the normal development of the embryo, including bones, but in adults Notch is almost inactive. Special structures (heterochromatin) that prevent the signaling pathway genes from working are responsible for turning off the signaling pathway genes. Unscheduled Notch activation can occur when heterochromatin is disrupted.
In a new study in mice, scientists show that unplanned activation of the Notch signaling pathway occurs during aging and leads to the bone loss seen in the elderly. This process is associated with an increased risk of fractures, including life-threatening fractures.
Using genetic modification, scientists created mice that lack the protein nicastrin, an important molecule in the Notch signaling pathway. This led to a significant increase in the mice’s bone mass and also restored the healing ability of bones lost during aging. Moreover, he was superior to the young animals.
The authors also found that blocking the Ebf3 protein shuts down the Notch signaling pathway. This means that drugs that target the inactivation of this molecule may reduce the risk of fractures in the elderly.
Previous scientists named Substances that can protect the brain against aging.
Source: Gazeta
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