Scientists from the National University of Singapore (NUS) have found that structures found in red blood cells can reduce the accumulation of fat in the arteries by affecting the immune system. Research has been published that could form the basis of a treatment for atherosclerosis. Journal of Extracellular Vesicles.
Atherosclerosis is a disease in which fat, cholesterol and other substances accumulate on the walls of the arteries. This leads to plaque buildup, which can clog blood vessels and cause heart attacks and strokes.
Extracellular vesicles are nanoscale structures secreted by various cells, including erythrocytes. In a new study, scientists found that it reduces inflammation in the wall of blood vessels by interacting with macrophages, which are immune cells. Second, it is an important factor in atherosclerosis.
Under the influence of extracellular vesicles, macrophages began to produce more of an enzyme that protects cells from oxidative damage, which is often seen in inflammatory and cardiovascular diseases. The ability of macrophages to absorb fats is also improved, which reduces their accumulation in the form of plaques on the walls of blood vessels.
The study could form the basis for effective atherosclerosis drugs after animal and human trials. Additionally, the anti-inflammatory effects of the vesicles may be useful in relieving other conditions associated with excessive inflammation.
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Source: Gazeta
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