Scientists from the RNIMU Institute for the Study of Aging. NI Pirogov found differences in the activity of several genes in Russian centenarians. The press service of the university reported this to socialbites.ca.
Scientists from the laboratory of genetics and epigenetics of aging analyzed DNA methylation profiles from tissue samples of 200 centuries-old Russians – 100 women and 100 men over 90 years old. The process of DNA methylation allows the body to regulate the activity of certain genes by adapting to the environment.
Geneticists have identified a number of candidate genes that may be unique to centuries-old Russians. The PRG3 and SERPINB2 genes showed a statistically significant change in expression (activity) in all tissues studied.
The development of chronic inflammation, another aspect of aging, is planned to be studied by biologists from the Russian National Research Medical University as part of the RussAge project. Scientists from the Laboratory of Aging Immunology of the Russian National Research Medical University compared the immune status of 250 centenarians under observation at the Russian Gerontological Research and Clinical Center of the Russian National Research Medical University. NI Pirogov. It turned out that only 10% of the patients had a healthy aging phenotype and did not suffer from senile weakness syndrome (asthenia). Pathological aging was observed in the remaining subjects, and the levels of inflammation biomarkers increased 10-20-fold.
In addition, Institute staff are working on plant senescence and age-related changes in the human extracellular matrix (ECM), whose properties determine the mechanical and biochemical properties of tissues and organs.
Source: Gazeta
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