In the next two years, experts from the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences plan to find out which genes are responsible for the regulation of blood pressure during stress, and to find new molecular targets for diagnostics and personalized. therapy. About this “socialbites.ca”, head of the laboratory of evolutionary genetics of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Doctor of Biological Sciences, Professor Arkady Markel.
“Molecular targets are what drugs for hypertension act on. There are many drugs for hypertension, but everyone is prescribed basically the same drugs, they act at certain endpoints in the blood pressure regulation circuit and do not allow the pressure to rise. And the drug must be taken continuously. And in this chain of reactions “We want to understand how it all started, what causes the pressure increase in the beginning, to find links that might be affected. Also, to influence it prophylactically so that hypertension never develops. This is an unsolved task.”
Because people differ in genotype, the molecular targets in different patients may also be different. Therefore, researchers are also looking for genetic or metabolic markers to point to these targets. This method will allow you to individually select for the patient drugs that will extinguish the disease on the way, depending on its genotype.
Studies are being done on mice, but the results transfer perfectly to humans, Markel said — the system for regulating blood pressure in mice and humans is almost the same as normal pressure — 120 by 80.
Read more about why hypertension develops due to stress and why people are starting to face the consequences of it more often than in prehistoric times – in material “socialbites.ca”.
Source: Gazeta
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