Researchers at the University of Eastern Finland conducted a comprehensive meta-analysis of dozens of publications that found that vitamin D supplements can improve symptoms in adults with depression. Article published in the journal Critical Reviews in Food Science and Nutrition.
The new meta-analysis linking vitamin D supplementation to depression is the largest meta-analysis ever published. It includes the results of 41 randomized, placebo-controlled studies in different populations from around the world. The results of a meta-analysis showed that vitamin D supplementation was more effective than placebo. There was wide variation in the doses of vitamin D used, but the average was 50-100 micrograms per day. Publications included in the meta-analysis did not look at the effects of sun exposure on vitamin D synthesis and also excluded patients with bipolar disorder.
The therapeutic efficacy of modern antidepressants is often insufficient, so additional ways of relieving the symptoms of depression through nutritional supplements are sought. Cross-sectional studies have shown an association between depressive symptoms and vitamin D deficiency, but not a causal relationship, so analysis results should be treated with caution. Also, previous meta-analyses of the effects of vitamin D supplementation on depression have not demonstrated its definitive efficacy.
The meta-analysis was carried out as part of an international collaboration between researchers from the University of Eastern Finland, Deakin University (Australia), Massachusetts Hospital Boston, Kuopio University, and the University of Helsinki.