American scientists from the Keck School of Medicine of the University of Southern California found that the accumulation of per- and polyfluoroalkyl compounds (PFAS) in the body worsens sleep, especially among young people. The study was published in the scientific journal magazine Environmental Developments (EnvAdv).
PFAS are widely used in consumer products, including nonstick cookware, waterproof clothing, and food packaging, to make the material impermeable to water and oil. These chemicals are called “forevers” because of their high resistance to degradation under natural conditions.
Substances of the PFAS family are associated with the development of cancer and various metabolic diseases, as well as disruptions in the body’s reproductive and immune systems, as well as disruptions in fetal development during pregnancy.
In the new study, researchers took blood samples and sleep information from 144 participants ages 19 to 24.
Four of the seven types of PFAS tested were significantly associated with reduced sleep duration or sleep quality (PFDA, PFHxS, PFOA, and PFOS).
It turned out that the presence of PPDK, PFHxS and PFOA in the body reduces sleep by approximately 80 minutes. High levels of many such substances are associated with even less sleep time.
Additionally, people with high levels of PFAS in their blood were more likely to report having trouble falling asleep, waking up frequently, and feeling tired while awake.
The team analyzed four types of PFAS using toxicology databases that compile studies linking chemicals, diseases, and changes in gene expression.
Researchers looked at more than 600 genes and found seven genes activated by PFAS and thought to affect sleep.
An important factor was the immune-related gene HSD11B1. It helps produce the hormone cortisol, which plays an important role in regulating the rhythm of sleep and wakefulness.
Another gene associated with sleep and PFAS is cathepsin B. It is related to cognitive function and memory. The enzyme it produces serves as the precursor of amyloid beta proteins found in the plaques in the brains of Alzheimer’s patients.
Previous scientists was created A new device to remove PFAS from sewage.