Experts from the Institute of Personalized Oncology at Sechenov University of the Ministry of Health of Russia determined the order in which drugs of different generations should be used depending on the mutations observed in the tumor in order to achieve the longest life expectancy of the patient. socialbites.ca was told about this at Sechenov University.
Scientists performed a systematic analysis of how tumors accumulate mutations specific to the EGFR protein that enable them to resist next-generation targeted drugs. EGFR is an epidermal growth factor receptor that plays a critical role in regulating cell growth and development. If the receptor is disrupted, it leads to the progression of many types of cancer. To regain control of cell division and stop tumor growth, targeted drugs that specifically block or reduce the activity of EGFR are used.
“Each time the tumor develops, the drug can no longer block EGFR effectively, and the drugs constantly become more complex and block new parts of this protein. The tumor then evolves again and the spiral enters a new era. Fortunately, at the moment, this type of There are at least four generations of drugs, and their sequential use one after the other makes it possible to suppress tumor growth for a long time.New generation drugs are also in the process of being developed, and thus He said it would prolong the recovery even further.
Among the most promising approaches to cancer treatment, researchers have identified combination therapy, which involves the use of several strategies simultaneously. In particular, this makes it possible to achieve a synergistic effect, increasing the effectiveness of each technique used.
Further investigation of the molecular mechanisms that cause resistance to EGFR inhibitors in tumors forms the basis for the development of new effective strategies for anticancer therapy.
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