Researchers from Imperial College London found that higher levels of caffeine in the blood of people who drank caffeine-based drinks were associated with a lower risk of obesity. results published In the journal BMC Medicine.
The study used data from 428,860 individuals from the UK Biobank, a large repository of biological samples. Researchers recorded participants’ caffeine consumption levels using self-report surveys. The researchers also collected information about the subjects’ health status and obtained genetic data on the caffeine concentration in blood serum.
Additionally, scientists performed metabolomic and proteomic Mendelian randomization analyzes on biological samples to determine the mechanisms of caffeine’s biological effects on the risk of developing osteoarthritis. Mendelian randomization is a method for examining measured variations in genes to examine the cause-effect relationship between a risk factor and a trait of interest (most often a disease).
The results showed that higher blood caffeine levels were associated with a lower risk of obesity in people who regularly drank caffeine-based beverages. Weight loss due to caffeine consumption was also indirectly associated with a 33% reduction in the risk of osteoarthritis.
Scientists believe that this positive effect of caffeine is caused by an improvement in the lipid profile (the content of fats in different fractions in the blood serum), a decrease in chronic inflammation in the body and changes in glycogen metabolism (this substance is a storehouse of glucose in the body).
Russians before said About the menace of instant coffee.