Relatives of men whose fertility is reduced due to low or absent sperm are more likely to develop cancer, including at a young age. This has been shown by a study published in the journal. Human Reproduction.
Scientists analyzed data from 786 men who consulted a doctor for pregnancy problems between 1996 and 2017. Their data was compared with information from 5,674 healthy men who had at least one child. The researchers also looked at cancer incidence in the men’s relatives using a U.S. population database.
Relatives of men without sperm had a higher risk of five cancers: bones and joints (156 higher risk), soft tissue (56 higher risk), uterus (27 higher risk), Hodgkin’s lymphoma (higher risk) by 60 percent, and thyroid gland by 60 percent. (54% higher risk).
Relatives of men with low sperm counts had a higher risk of developing three types of cancer: colon (16% higher risk), bone and joint (143% higher risk), and testicular (134% higher risk). But they were 61% less likely to develop esophageal cancer.
Scientists suggest that some genetic characteristics can both impair a man’s fertility and increase the risk of cancer in his relatives. More research is needed to determine the nature of the link. This will allow doctors to make more accurate cancer risk predictions for men with fertility problems and their families.
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