Marezin 1 repaired the damaged muscles of the animals and increased their strength. This has been shown by a study published in the journal. e-Life.
Muscle loss is common after surgery and injury. This process is accompanied by inflammation and scarring (fibrosis), that is, the replacement of muscle tissue with non-contractile connective tissue. In a new study, biologists examined the molecules involved in this change.
The authors focused on lipid inflammatory mediators that are partially responsible for inflammatory immune responses. It turned out that the lipid mediator Maresin 1, when introduced into an artificially damaged muscle, reduces the number of immune cells of neutrophils and macrophages. This indicates that inflammation has decreased. Additionally, the muscle strength of the mice in which this experiment was performed also increased.
The study’s findings highlight the role of lipid mediators in regulating inflammation and may form the basis of the first effective treatment for acute muscle wasting.
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