Scientists from the Hubrecht Institute in the Netherlands have created the first model of the human conjunctiva. The organoid model can be used to test drugs for various diseases affecting the conjunctiva. Research results published In the journal Cell Stem Cell.
Conjunctiva is the tissue that covers the white part of the eye and the inner surface of the eyelids. It performs protective, moisturizing and barrier functions, and also plays a role in tear secretion.
To better understand the composition and function of this tissue, scientists used human conjunctival cells and transformed them into three-dimensional structures. It is called organelle. The researchers noted that no conjunctiva model suitable for careful study had previously been developed.
With the help of a new development, scientists have managed to unravel how the conjunctiva plays a role in tear production. It turns out that the mucous membrane produces not only fluid, but also special antimicrobial components that can fight pathogens. In an experiment based on simulating an allergic reaction, it was found that allergies produce more tears and antimicrobial substances.
Also during the research, scientists discovered a new type of cells in the structure of organoids – tuft cells. It turned out that their number increases in conditions of allergic reactions.
The researchers added that the organoid model opens new possibilities in researching diseases affecting the conjunctiva. The development is also suitable for testing drugs for allergies or dry eye syndrome.
It was like that before discoveredeyes can determine the development of mental abilities.