Inflammation of the gums (periodontitis) due to bacterial infection aggravates chronic obstructive pulmonary disease (COPD). This was shown by a study by scientists from Sichuan University published in the journal. mSystems.
According to the World Health Organization, COPD ranks sixth among the causes of death in the world. This disease is incurable and greatly reduces quality of life. The leading cause of COPD in high-income countries is tobacco smoking, and in low- and middle-income countries it is tobacco smoking and air pollution.
In a new study on mice, scientists found that bacteria P. gingivalisIt contributes to the development of COPD, which is involved in gingivitis. This effect is associated with the activation of two types of immune cells: γδ T cells and M2 macrophages. Blocking their activation with medications could potentially help treat COPD.
Previous studies have shown that bacteria P. gingivalis It can migrate from the gums to the lungs and cause inflammation there. Additionally, gingivitis is associated with an increased risk of diabetes and hypertension. Scientists now plan to test whether treating periodontitis can improve the condition of COPD patients and reduce inflammation in lung tissue.
“Our discovery could potentially lead to a new treatment strategy for COPD,” the authors concluded.
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