Researchers from Miami State University in the USA have identified the reason why glioblastoma is resistant to treatment. It turns out that cancer cells mimic neurons to evade therapy. The results of the scientists’ work were as follows: published In the journal Cancer Cell.
Glioma is a tumor that affects glial cells in the brain or spinal cord. This is the most common primary tumor and is also the most serious and most difficult to resect brain tumor. Glioblastoma is considered an incurable disease; The average survival rate of patients is approximately 15 months.
The study authors used a platform designed to examine the entire set of proteins in glioblastoma cells and specific modifications of these proteins that indicate enzyme activity in the cells. It turns out that the BRAF protein may be a potential target for glioma treatment; It remains unchanged and can “give away” by mimicking cancer cells.
Tests of a BRAF inhibitor (a substance that suppresses various processes in cells) in mouse models were successful. In the future, scientists will continue to research and develop new treatment tactics.
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