Scientists from the Perelman School of Medicine of the University of Pennsylvania (USA) discoveredIt turns out that a compound called 4-phenylbutyrate (PBA), which can clear toxic protein buildup in the brain caused by Alzheimer’s disease, can reduce or delay the progression of the disease in mice. The results were published in the journal Biology of Aging.
4-phenylbutyrate (PBA) is a fatty acid molecule that prevents toxic proteins associated with Alzheimer’s disease from accumulating in the brain. These include, for example, amyloid proteins and tau proteins. This substance can restore proteostasis, a state of balance in which a cell or body maintains its proteins.
Experiments involving laboratory mice have shown that administering PBA via intraperitoneal injection helps reduce proteotoxicity, which is cell damage caused by the accumulation of misfolded proteins. Young rodents with spatial coordination problems who received therapy were better able to distinguish between moving and stationary objects in one test of cognitive ability. It also turned out that the use of a drug based on 4-phenylbutyrate in middle-aged mice helped eliminate memory deficits in rodents.
It was noted that with subsequent treatment, the number of amyloid plaques in the animals’ brains and the intensity of the process that led to their formation decreased. An additional advantage of such drugs is that they can penetrate the brain through the bloodstream.
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