Flavonoid diosmin supplementation effectively reduces swelling after total knee replacement. This has been shown by a study published in the journal. Journal of Bone and Joint (JBJS).
For people with severe osteoarthritis or arthrosis, total knee replacement, that is, replacement of all its parts with artificial ones, is indicated. Postoperative swelling causes severe pain, hinders patient recovery, and no effective medication is currently available to reduce it.
The new study included 330 patients who underwent arthroplasty at 13 university hospitals. For two weeks from the first day of surgery, patients were given diosmin supplements and painkillers or only painkillers.
In patients taking diosmin, swelling in the knees, calves, and thighs decreased more quickly within 14 days. They also had less pain when moving their knee. Resting pain, recovery scores, and inflammation levels did not differ between the experimental and control groups. Short-term complication rates were also similar between groups, confirming the safety of diosmin.
The study provided preliminary evidence that diosmin is a safe and effective treatment to reduce swelling and pain with movement after arthroplasty. However, given that the analysis did not reveal any differences in inflammatory biomarker levels between groups, questions remain regarding the mechanism of action.
Diosmin is a flavonoid obtained from citrus fruits. It has an antioxidant effect, that is, it protects cells from the damage of highly active radical molecules. Diosmin has also shown some effectiveness in reducing swelling of the extremities in patients with venous disease.
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