Changes in the number of certain types of bacteria in a person’s microbiome may indicate urolithiasis. This conclusion was reached by a scientific team that included scientists from the University of Western Ontario (Canada). Research results published In the journal Microbiome.
The gut microbiome is the collection of all microbes living in the human body, including the skin, mammary glands, genitals, lungs, mucous membranes, biliary tract, and gastrointestinal tract. In the study, scientists evaluated the status of the intestinal microbiome, urinary tract and salivary glands in 83 patients with kidney stones and 30 healthy volunteers. To identify the functions and numbers of specific bacteria, the clinical method of metagenomic sequencing was used; A comprehensive analysis of the genetic material of microorganisms and hosts from clinical samples.
Scientists found that the composition of the microbiomes of the salivary glands, intestines and urinary tract changes in patients with urolithiasis. In particular, a decrease in overall bacterial diversity was observed, as well as a decrease in the abundance of lactobacilli, Gardnerella vaginalis, Prevotella sp, and Campylobacter sp. It has also been revealed that bacterial imbalance in the intestines is associated with the excretion of various toxins into the kidneys.
Previous scientists developed A new drug for the prevention of atherosclerosis.