Pulmonologist Carmona Porquera, who is part of a research team at Mayo Clinic developing new ways to diagnose and treat pulmonary fibrosis, said the cause of this dangerous disease may be shortening of telomeres. In this respect reports Mayo Clinic.
The expert explained that some patients with pulmonary fibrosis have shortened telomeres, the ends of chromosomes that play an important role in the aging process. They protect DNA strands from damage and loss of genetic information. The pulmonologist added that disorders in the biological structure of telomeres are caused by rare genetic mutations. Patients with this disorder have an increased risk of developing liver fibrosis, osteoporosis, and cancer.
Pulmonary fibrosis is a pathological process of proliferation of connective tissue with gradual replacement of pulmonary alveolar tissue. Alveoli are small sacs located at the ends of the bronchioles and surrounded by a dense network of capillaries where gas exchange occurs. Stiff connective tissue does not participate in gas exchange, as a result, respiratory function decreases.
It is stated that not all telomeres shorten at the same time. The cause of the development of pulmonary fibrosis may be a decrease in the length of one or both terminal segments. Scientists at the Mayo Clinic previously developed a special method for measuring telomeres called Telogator. Its use makes it possible to increase the effectiveness of early diagnosis of pulmonary fibrosis.
Antifibrotic drug therapy is widely used in this disease. Patients are also advised to quit smoking and maintain a healthy lifestyle. Scientists believe the ability to detect shortened telomeres will allow patients to live longer, more fulfilling lives.
Previously named Alarming symptoms of lung cancer in non-smokers.