The study identified biomarkers that may in the future make it possible to assess, without biopsy, whether the kidneys are healing properly in acute renal failure. The results of the study were published in the journal Science Translational Medicine.
Acute kidney failure can cause loss of kidney function, and doctors have long been searching for biomarkers that would provide information about a patient’s condition without invasive kidney biopsy, that is, without the need to remove tissue directly from the organ for analysis.
In the new study, doctors examined a total of more than 120,000 cells from kidney biopsy samples from 17 patients with acute kidney failure and seven healthy participants. Six specific proteins associated with maladaptive renal proximal tubular repair were identified in patients. This process is accompanied by severe inflammation, and its identification using the proteins the scientists discovered will allow for a better prognosis and treatment of acute kidney failure.
“Patients with acute kidney failure are often critically ill in the intensive care unit, and kidney biopsies are not possible due to safety concerns. There is an urgent need to identify tissue signatures in blood or urine that can tell us how the kidneys are healing,” said study author Chirag Parikh, MD, director of nephrology at Johns Hopkins Medical Center. ” said.
Previous scientists I learnedIt is stated that this special sugar can reduce the risk of cystitis in the elderly.