Vanderbilt University scientists found that thiazide diuretics can reduce the risk of kidney stones by 15%. The study was published on: JAMA Network Open.
Kidney stones affect almost 10% of the world’s population. Thiazide diuretics, commonly used for high blood pressure, have been the standard treatment for kidney stones for more than three decades because they reduce urinary calcium excretion. However, recent clinical studies have raised doubts about their effectiveness. The NOSTONE study, published in NEJM in March 2023, did not find a protective effect of thiazide diuretics on urolithiasis.
A new study involving more than a million patients challenges these findings. Scientists have found that genetic traits that mimic the effects of thiazide diuretics are associated with a 15% reduction in the risk of kidney stones. Additionally, patients with these features had higher serum calcium levels. This supports the view that thiazides affect the risk of kidney stones by regulating urinary calcium excretion.
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