A combination of two experimental drugs has been shown to be effective in treating difficult-to-treat peripheral nerve sheath tumors. The research was published in the journal Molecular Cancer Therapies.
A study in mice showed that the combination of two experimental drugs, one blocking the metabolism of the amino acid glutamine and the other blocking the recycling of purines (the building blocks of DNA), reduced the size of peripheral nerve sheath tumors and increased survival. animals. The therapy was also less toxic than existing treatments.
Previous research by the new study’s authors showed that treating mice with a drug that blocks glutamine utilization led to a partial reduction in tumors. But tumors can still access purines by recycling them. The second drug aims precisely to deprive them of this opportunity.
“Glutamine is a building block for proteins and many other large molecules that cancer cells need to grow, proliferate, survive, and potentially spread,” the scientists explained.
Malignant peripheral nerve sheath tumors are rare types of cancer that occur in the nerve sheath. Chances of survival depend on whether the tumor can be completely removed with surgery, whether it responds to traditional chemotherapy, and how widely the cancer has spread.
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