Researchers at the University of Barcelona have discovered that a protein known as the immune receptor CD300f plays a crucial role in determining the lifespan of mice. Furthermore, the absence of CD300f is associated with the early onset of cognitive decline. results published In Cell Reports.
The CD300f receptor is a protein expressed by immune system cells that modulates cellular metabolism and triggers inflammation. To find out what functions the laboratory mouse performs in its body, scientists conducted a study based on detailed monitoring of various groups of animals over a period of thirty months. The length of the experiment allowed scientists to abandon the use of accelerated aging models that did not accurately reflect the process, which includes the gradual accumulation of changes with age.
The study found that the immune system’s CD300f and myeloid cells (derived from progenitor cells (monocytes, red blood cells or platelets)) may determine the rate of occurrence of aging-related pathologies. Specifically, scientists found that mice lacking the immune receptor CD300f prematurely developed diseases and disorders such as cognitive deficits and impaired motor coordination. The absence of such pathologies contributes to healthy aging and longevity.
Additionally, CD300f protects certain organs (brain, liver, and lungs) from damage. The mechanisms underlying this function remain to be investigated. The scientists hope their discoveries will lead to the development of therapeutic strategies aimed at treating dementia in humans.
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