Researchers from Michigan State University (USA) found that dietary fiber deficiency normalizes intestinal microflora in Crohn’s disease in mice. results published In Cell Host and Germ.
Crohn’s disease is an inflammatory disease of the gastrointestinal tract in which granulomas, accumulations of macrophages (specialized immune cells), can form anywhere in the digestive tract. Exacerbations of the disease are often accompanied by fever, abdominal pain and diarrhea.
Scientists have found that a low-fiber diet can improve the quality of life of people with this disease. Fiber is fiber obtained from plant foods that the human body cannot digest. They contribute to the normal functioning of the intestines of a healthy person and serve as a food source for bacteria living in the intestine.
Elimination of dietary fiber was found to reduce the abundance of fermentative hydrogen-producing microbes (family Lachnospiraceae) in the intestines of laboratory mice with Crohn’s disease. Hydrogen bacteria are not pathogenic organisms. They play an important role in biochemical cycles by breaking down complex organic compounds into simpler ones and increasing the availability of nutrients.
The decrease in the intensity of enzymatic hydrogen production led to a decrease in the number of Mucispirillum bacteria in the intestinal mucosa. Scientists noted that colonization of the intestines by these bacteria may trigger the inflammatory feature of Crohn’s disease.
Scientists stated that the results of their study allow us to better understand the complex interaction between nutrition, intestinal microflora and digestive system diseases. The researchers hope their work will lead to the development of new nutritional strategies for patients with Crohn’s disease.
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