Scientists from Roman Catholic University modified the LIMK1 protein to improve memory. The research was published in the journal Science Developments.
The LIMK1 protein plays a critical role in the formation of dendritic spines, structures on the surface of nerve cells in the brain that are essential for learning and memory. In the new study, scientists genetically modified the LIMK1 molecule in mice by adding a “molecular switch” to its shell that was activated by administration of the drug rapamycin. Rapamycin, which suppresses the immune system, has previously been shown to extend the lifespan of animals and improve their mental abilities.
In animals with age-related memory and learning disabilities, using gene therapy to replace the LIMK1 protein and activate it with rapamycin led to significant improvements in mental abilities. The work paves the way for the development of artificial proteins for the treatment of brain disorders.
“The next step will be to test the effectiveness of this treatment in experimental models of neurodegenerative diseases that show memory deficits, such as Alzheimer’s disease. The authors noted that further studies will also be needed to confirm the use of this technology in humans.”
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