Scientists and the Charite Clinic have found that antibiotics may reduce the risk of organ damage due to hypertension. Scientists reported that this effect is associated with changes in the composition of intestinal microbes. ASN Kidney Week 2023The world’s largest meeting of nephrologists.
For the experiment, biologists used narrow-spectrum antibiotics to destroy gram-negative or gram-positive bacteria in rats with hypertension.
The antibiotic vancomycin (against gram-positive bacteria) led to a reduction in heart size and alleviated kidney damage. Treatment with polymyxin B (against gram-negative bacteria) had no significant effect. But antibiotics did not affect blood pressure levels. Scientists believe that vancomycin’s effect may be due to reduced inflammation in the animals’ organs.
The fact is that vancomycin treatment led to a significant increase in the number of lactobacilli, which are considered “beneficial” gram-positive bacteria. When the researchers examined immune cells isolated from the heart, kidney, blood, spleen and intestines of mice with hypertension, they found many signs of inflammation. Vancomycin treatment reduced inflammation in the kidneys, but polymyxin B had no effect on inflammation.
“Our study shows that altering the gut microbiota, in this case through oral administration of nonabsorbable antibiotics in a rat model, can attenuate hypertensive kidney damage and inflammation, independent of blood pressure. “In the future, we would like to achieve such effects without the use of antibiotics,” said Immanuel Wimmer from Charité Clinic Moritz. .
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