Restricting calories by even 12% can increase your chances of healthy aging by reducing inflammation. This was reported in a study published in the journal Science by scientists from the National Institute on Aging (NIA). Aging Cell.
Many studies have shown that calorie restriction in animals, without depriving the body of essential vitamins and minerals, slows the development of age-related diseases, prolongs life, improves its quality and resistance to stress. New research suggests that this effect extends to humans.
Scientists analyzed patient data from the CALERIE study. Participants were healthy young and middle-aged Americans without obesity. They were asked to reduce their daily calorie intake by 25% for two years. However, the maximum rate achieved was a 12% reduction.
Researchers found that this small calorie restriction had the same effect in humans as it did in animals. For example, it activated genes responsible for energy production and metabolism while also suppressing pro-inflammatory genes. Regulation of circadian rhythms and restoration of damaged DNA regions also changed.
Because inflammation and aging are closely linked, calorie restriction is a powerful approach to preventing the inflammatory condition that many older adults develop. The authors concluded that reducing calorie intake by 12% is possible and may be very beneficial.
Additionally, the authors of the original Phase 2 CALERIE study, whose results were published in the journal Nature Aging, showed that calorie restriction slowed the rate of aging by 2-3%. Additionally, trial participants lost an average of 10% of their body weight over the next two years and gained almost no weight.
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