Scientists from the Institute of Solution Chemistry GA Krestova RAS (Ivanovo) and the Catholic University of Leuven (Belgium) have developed a substance based on dyes of various classes, which will help improve the diagnosis of blood diseases. The Russian Science Foundation (RSF) reported this to socialbites.ca.
The substance contains two dyes of different classes – BODIPY and porphyrin. Porphyrin is a chemical that is part of hemoglobin, a protein that carries oxygen to body tissues. Acting in conjunction with BODIPY, a fluorescent dye used as a bright marker in the diagnosis of various diseases, the new compound has the ability to produce “active” oxygen to destroy pathological cells in the body.
Scientists combined porphyrin and BODIPY molecules into a single system; this increased the ability of porphyrin to produce “active” oxygen and improved the detector properties of BODIPY. This means that the substance can simultaneously perform a therapeutic function and serve as a marker of pathogenesis (to indicate the occurrence and development of advanced diseases). The compound tracks subtle changes in the viscosity or acidity of cellular fluid that are associated with both the disease itself and the outcome of the treatment.
Researchers noted that based on the new substance, it is possible to create “smart” molecular devices to monitor physiological and pathological processes in the blood and evaluate the effectiveness of treatment of diseases in general.
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