Scientists from the University of California discovered that HIV-infected people who are also carriers of Kaposi’s sarcoma-associated herpesvirus (KASV) develop cancer due to the immune dysfunction caused by KAPOSI. The results of the scientists’ work were presented in the journal PLOS Pathogens.
HCV has long been known to cause cancer in people living with HIV. It causes a cytokine storm in the human body, but the mechanism of development of such an immune response was unknown. In the new study, the authors used cell sequencing methods, mass cytometry, and a herpesvirus model.
Researchers have found that HCV infection infects monocytes (large white blood cells). This stimulates the production of macrophages, cells that can actively capture and digest bacteria, debris from dead cells, and other particles that are foreign or toxic to the body. Macrophages are less likely to activate T cells that are also immune. T cells can protect against cytotoxic harmful effects on the body, but due to their low activity, the person’s immunity is weakened.
As a result, inflammation in the body increases and the infected person becomes vulnerable to secondary infections and cancer development.
former oncologist named An unexpected sign that indicates the risk of developing esophageal cancer.