Scientists from Seoul National University (SNU) have developed stem cell and cerium-based nanoparticles to treat rheumatoid arthritis and instantly relieve pain. The research was published in the journal Nature Nanotechnology.
Rheumatoid arthritis is a chronic disease accompanied by joint inflammation that occurs as a result of the attack of the immune system. Current treatment may only provide pain relief but does not address the root cause of the disease: a malfunction in the immune system.
In a new study, scientists tested nanoparticles obtained from stem cells by placing cerium nanoparticles on them. The therapy restored immune function after the first dose in mice with rheumatoid arthritis. Repeated administration of the drug significantly reduced the frequency and severity of symptoms, confirming the preventive potential of these nanoparticles.
Cerium effectively reduced the production of reactive oxygen species (radicals) that damage cells and cause inflammation. It also triggered the conversion of M1 macrophage immune cells to M2, providing immediate relief of inflammation and symptoms, and stem cell-based nanoparticles reduced inflammation by preventing the transformation of dendritic immune cells into tolerogenic dendritic cells.
Previous scientists I learnedImproving a person’s mobility can increase their chances of earning a good income.