Researchers from Kyung Hee University in Seoul have identified a link between the functioning of the gut microbiome and the risk of developing schizophrenia. Research results published at the Multidisciplinary Digital Publishing Institute (MDPI).
The intestinal microbiome contributes to the formation of mucus in the stomach, ensures the functioning of digestive enzymes, vitamin synthesis, and modulates the immune system. The microbiome is also an important component in regulating brain activity through the enteric (gut) nervous system, immune, endocrine systems, and metabolism.
Analysis of the gut microbiota of patients with schizophrenia has shown that people with this disease often have impaired lipid and glucose metabolism and also have low bacterial diversity. Additionally, their bodies are low in SCFA acids such as acetate, propionate and butyrate. These acids protect the brain from toxins and are responsible for cognitive abilities.
It also found that gut dysbiosis can lead to reduced brain neuroplasticity (the ability of neural networks to grow and change through reorganization), potentially increasing the tendency for aggressive behavior.
Scientists noted that the study may contribute to the development of innovative approaches to the treatment of schizophrenia aimed at normalizing the intestinal microbiome.
Previous scientists taught Artificial intelligence to diagnose schizophrenia.