Scientists from the Van Andel Institute (USA), together with colleagues from France and Italy, have created a model that allows them to trace how Alzheimer’s disease develops in the brain. To do this, they transplanted human stem cells into mice. Research results It was published at BioMed Central (BMC).
Studying Alzheimer’s disease is difficult because there are few noninvasive methods to monitor the progression of the disease in the human brain. Often scientists rely on simulation models.
The new technology is a model based on induced pluripotent stem cells. These are undifferentiated (immature) cells that can develop into various organ and tissue cells, including neurons.
However, brain cells can function within a special ecosystem that cannot be separated from tissues. Scientists used mouse brains as a container for human stem cells.
It turned out that thanks to this method it is possible to observe many processes characteristic of Alzheimer’s disease – the formation of protein plaques, the ability of pathology to spread, inflammation.
Researchers noted that experiments involving rodents have already made a major contribution to the study of Alzheimer’s disease. The new model will allow us to understand how the disease develops over a longer period of time.
previous doctors I found a link Between vigorous walking and reduced risk of cancer and dementia.