Japanese scientists from the University of Tsukuba found that the plant alkaloid trigonelline (TG), found in coffee, stimulates brain functions associated with memory and spatial thinking. This has been shown by experiments on mice with accelerated aging. To work published In the scientific journal GeroScience.
The researchers fed aging laboratory mice TG for 30 days and then placed the rodents in the Morris water maze (a small pool with a hidden platform underwater). It turned out that the animals receiving trigonelin found the rescuer candidate faster than the mice that were not given the substance.
To examine the underlying molecular mechanisms, scientists analyzed the hippocampus (the region of the brain responsible for short-term memory) of experimental mice.
They found that THs significantly affect signaling pathways associated with neurodevelopment, mitochondrial function, inflammation, and neurotransmitter release. Trigonelin suppressed neuroinflammation and also accelerated the transmission of dopamine, norepinephrine and serotonin, eliminating cognitive impairments that occur with aging.
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