Scientists from the University of Virginia School of Medicine have found that as some immune cells age, their ability to produce energy decreases due to impaired calcium metabolism. In this process, targeted drugs can help fight aging and related diseases. Research published in the journal nature aging.
Mitochondria are the structures responsible for producing energy in cells. These “powerhouses” require calcium, but as we age our ability to absorb and use it decreases.
When this process occurs in macrophage immune cells, the process leads to persistent inflammation in the body. It has previously been associated with many age-related problems, including dementia and cancer.
Scientists have identified the precise molecular mechanism behind this process. Taking calcium supplements alone will not help restore calcium levels in the mitochondria. But researchers think targeting the cause of this deficiency will help reduce chronic inflammation and improve immune function in older people.
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