Scientists at Nagoya University have discovered previously unknown proteins that could improve the diagnosis of ovarian cancer, one of the most dangerous malignant tumors in women. Research published in the journal Science Advances.
Ovarian cancer is difficult to diagnose, so it is often detected in the late stages. It is estimated that after ovarian cancer is detected in the first stage, approximately 90% of women will live for five years or more, and the rate of those who live for five years or more in the fourth stage decreases to 20%. (according to other estimates – up to 5%).
One approach to detecting cancer is to look for proteins released by the tumor. They can be found in body fluids such as blood, urine, and saliva. However, reliable biomarkers for ovarian cancer have yet to be discovered.
In the new study, the scientists found three previously unknown FRα proteins, claudin-3 and TACSTD2. They extracted them from the tumor using antibodies and a polyketone-coated nanowire. Biologists are working with high-grade serous carcinoma (HGSC), the most common type of ovarian cancer.
The results showed that each of the three identified proteins is useful as a biomarker for HGSC. This means they can form the basis of early detection of ovarian cancer and predict the course of treatment.
ancient scientists in your name Occupations associated with a higher risk of ovarian cancer.