Specialists of the Russian National Research Medical University Institute for the Study of Aging. NI Pirogov, director of the Institute for the Study of Aging of the Russian National Research Medical University, VINI Pirogov Alexey Churov of the Russian Ministry of Health.
Based on the Cellular Mechanisms of Aging lab, scientists are testing two groups of drugs with geroprotective properties.
“These are hydroxycoumarin derivatives and berberine derivatives (a substance naturally found in plants such as barberry and goldenseal). Their bioavailability, effects on cell death and other parameters are evaluated.
One of the drugs, a derivative of hydroxycoumarin, showed the first good results, it has already been patented. It will now be studied on mouse models,” Churov explained.
As for berberine, it is an alkaloid long used in Chinese medicine, it has many beneficial pharmacological properties, including anti-inflammatory effects. The first tests of its derivatives are scheduled to begin this year.
“If all goes well, then we will have two domestic geroprotectors. The idea is to improve the chemical properties of substances that already exist in nature,” the expert concluded.
Read more about why Russian doctors collect the biodata bank of centenarians, why scientists create new clocks of aging, what immunomodulators work, and why telomeres cannot be a marker of aging. report “socialbites.ca”.