Scientists at Perm Polytechnic University have developed a two-level mathematical model to help experts repair cardiovascular tissue vessels in the most efficient and safe way. The results of the study were published in the journal materials.
The resulting technology will help prevent destruction during the insertion of the coronary stent (a special frame inserted into the lumen of the hollow organs of a human or animal) and make it durable when used. Thus, Russian doctors have solved the problem of biomechanics in this field.
Doctors use coronary stents to widen blood vessels and allow adequate blood flow throughout the body. They are made from metal alloys and biopolymers. However, when used, there is a risk of rupture with subsequent damage to the vessels.
The researchers decided to learn how to precisely control the properties of the products and adjust their structure, the supporting “frame”, and at the macroscopic level. To do this, they identified the most dangerous types of deformation during the insertion of a balloon-expanded stent into a vein.
Roman Gerasimov, a junior researcher in the Laboratory for Modeling Multilevel Structural and Functional Materials at PNRPU, said Russian scientists have performed simulations using a program that includes macro- and intermediate-level physical mechanisms and deformation processes. He identified all the “weak” places of the stent.
As a result, data obtained at macro and mesoscopic levels will allow biotechnologists to control the properties of such medicinal products, determine their structure and prevent damage during installation in a human vessel.